Understanding the role of the endocannabinoid system

A Modernized Problem 

Our bodies are constantly seeking homeostasis. In other words, to have a balanced system without inflammation. But it’s difficult to do in the modern world because of:

  • Leaky gut: very common due to processed foods, in which your gut isn’t functioning optimally and secretes the chemicals from the food and bacteria into the bloodstream, leading to fatigue, bloating, diarrhoea and such like
  • Air pollution: both indoors and outdoors. Whether that be traffic-related air pollution from combustion, mould, pollen and dust in your home, inhalation of pollutants causes inflammation of the nasal passages, watery eyes, respiratory irritation and fatigue. Even the exacerbation of atherosclerosis that causes heart attack and stroke
  • Stress: the pressures of raising a family and earning an income in a fastpaced world. Such inflammation in the brain leads to sleep disorders like insomnia, anxiety and depression
  • Sedentary lifestyle: most of us clock in and clock out, and in the 8-9 hour intervening period, sit at the desk for the whole day. Especially if you’re not exercising before or after work, your energy expenditure is extremely low, and only 21% of people are attaining the proper amount of exercise

Because of this constant barrage, your body can’t produce sufficient cannabinoids to bring balance. Your endocannabinoid system (ECS) will try, but will most likely fail to bring balance.

The role of the endocannabinoid system

Your ECS, which exists in all of us, has three main purposes:

  1. To pair cannabinoids and endocannabinoids with endocannabinoid receptors. Cannabinoids will be the external source from CBD supplements or smoking marijuana, and endocannabinoids are naturally produced within our bodies. The two main ones are anandamide and 2AG; the former is released in the likes of meditation and yoga, and the latter from mothers milk and ‘runners high’
  2. Synthesis of enzymes that will degrade cannabinoids to maintain the correct amount from an external source
  3. The production of endocannabinoids

The endocannabinoid system has 2 main receptors: CB1 and CB2 – meaning cannabinoid receptor 1 & 2.

Role of the endocannabinoid system
CB1 & CB2 play distinctly different roles in body regulation

With all of this comes a positive influence on your mood, energy levels, sleep, memory and much more. So you can see from the image how CB1 is associated with nerve cells of the brain and spinal cord primarily. Then CB2 is more widely dispersed in the body, and bonded to white blood cells, hence the role in the immune system.

The benefits of the endocannabinoid system 

The role of the endocannabinoid system in providing benefits are linked to the cannabinoid receptor functionality. You can see from the infographic that CB1 will positively influence mood, stress and anxiety, whilst CB2 is for boosting immunity.

Moreover, CBD is great for appetite improvement and suppression, as well as boosting your metabolism.

CBD Timeline Part 2 

Reefer Madness is on YouTube; the full movie and in pretty good quality.

The cannabis timeline above is the second half of the brief history documentation; you can find the first half here. I do find it fascinating that THC was first isolated in Isreal, of all places, by the renowned Israeli scientist, Raphael Mechoulam in the 1960s. That’s why over 10,000 patients are administered medical marijuana in Israeli hospitals and care homes to help the elderly with pain alleviation from arthritis and abating mood swings associated with Alzheimer’s and for cancer patients.

The ECS was first identified in the 1970s but the role of the endocannabinoid system wasn’t fully accepted until the 1990s when anandamide was first identified.

Administering CBD Oil

Taking CBD as a supplement helps boost the role of the endocannabinoid system. There is such a thing as CECD: clinical endocannabinoid deficiency, so everything from inflammation, epilepsy, seizures, pain, Alzheimer’s, multiple sclerosis, insomnia, depression and nausea cannot be addressed.

Furthermore, it’s great for PTSD (post-traumatic stress disorder) sufferers as CBD improves sleep quality, which in turn helps with the deletion of old memories. In this case, it’s the unpleasant flashbacks from wartime, a car crash or abusive relationship, for example. The ability to cycle between REM (rapid eye movement), the sleep-dreaming stage and NREM (non-rapid eye movement) sleep helps with the ‘recycling’ of memories, so to speak. Old memories no longer required are deleted from your brains memory bank, whilst new information is stored. CBD oil enhances sleep quality, which in turn aids in the preferential selection of memories.

Whilst targeted memory reactivation is important to consolidate new information, its equally important for your brain to delete redundant information, especially with connotations of pain/suffering. CBD and the role of the endocannabinoid system provide this.

What if you’re completely healthy?

CBD supplementation boosts the ECS by slowing down the production of the enzyme FAAH, which breaks down anandamide. What’s more, CBD supplements include essential minerals, vitamins, fibres and fatty acids. Coupled with anandamide top-up, it can enhance mood and productivity in even the healthiest of people.

In a modernized world where sleep deprivation and stress from work is inescapable, CBD will reduce neuroinflammation. Our immune system is hampered nowadays in the developed world, so I urge you to give it a try.

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Hello everyone, I'm Donald Eide, founder of Honey Gusto. We specialize in the manufacturing and selling of medical devices and supplies. Our purpose is to have these devices available to everyone across the globe. We make the process simple. Nobody want's to be overwhelmed when they buy a medical product, whether that be an allergy test kit or an earwax removal product. We've got you covered with user simplicity. It could be a custom-designed instructional comic, 2-D animated video or a live product demonstration. We ditched the old-fashioned black and white instruction leaflet and introduced an engaging way to learn. All our instructions are simple to understand. And trust me, they aren't boring. You can rest assure that you will have a stress-free experience with our products, whilst picking up new skills and knowledge on health and well-being. You can feel proud knowing you can manage the health of yourself and your family. That's my goal for everyone who uses our products. I wish you all the very best of health. Donald Eide


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